Adjunct Assistant Professor
Dora Cavallo-Medved, Ph.D.
Dora Cavallo-Medved, Ph.D.
University of Windsor
401 Sunset Ave. Rm. 110 BB
Office Phone519-253-3000 x4750
Dora Cavallo-Medved is a faculty member in the Department of Biological Sciences at the University of Windsor (Windsor, ON, Canada) and an Affiliate Assistant Professor in Pharmacology at Wayne State Univeristy. Her main research interest is on the development of 3-dimensional cellular models to study both the breast and prostate tumour microenvironment. In particular, she is interested in the role of proteases on tumor cell invasion and on tumor-stromal interactions. Her research objectives are to elucidate the molecular mechanisms that are regulating protease expression and activity within the cancer microenvironment in an effort to identify novel therapeutic strategies against the disease.
In addition to her research, Dr. Cavallo-Medved is also a founding and executive member of the Windsor Cancer Research Group. She chairs the Public Outreach and Education committee and is directly involved in creating cancer research opportunities in Windsor-Essex as well as cross-border (Windsor-Michigan) research networks. She is also involved in engaging undergraduate and graduate students in the development of cancer-related educational tools and public outreach educational programs. Her research in science education creates opportunities for students to partner with faculty and work collaboratively to foster their professional development.
BSc (Honours) - Biological Sciences, University of Windsor
MSc - Biological Sciences, University of Windsor
PhD - Chemistry and Biochemistry, University of Windsor
Postdoctoral Fellowship - Pharmacology, Wayne State University
Areas of Expertise
Areas of Interest
Areas of Research
Bazzi ZA, Balun J, Cavallo-Medved D, Porter LA, Boffa MB. Activated thrombin-activatable fibrinolysis inhibitor attenuates the angiogenic potential of endothelial cells: potential relevance to the breast tumour microenvironment. Clin Exp Metastasis. 2017 Jan 25. doi: 10.1007/s10585-017-9837-y. [Epub ahead of print] PMID: 28124276
Bazzi, Z.A., Lanoue, D., El-Youssef, M., Romagnuolo, R., Tubman, J., Cavallo-Medved, D., Porter, L.A., Boffa, M.B., Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) attenuates breast cancer cell metastatic behaviors through inhibition of plasminogen activation and extracellular proteolysis, BMC Cancer, 16, 328, 2016, May.
Rezaeian, I; Tavakoli, A; Cavallo-Medved, D; Porter, LA; Rueda, L, A novel model used to detect differential splice junctions as biomarkers in prostate cancer from RNA-Seq data, J Biomed. Inform., 60, 422-430, 2016, April.
Ji, K; Heyza J; Cavallo-Medved, D; Sloane, BF, Pathomimetic cancer avatars for live-cell imaging of protease activity, Biochimie, 12, 2015.
Cavallo-Medved, D., Moin, K. and Sloane, B.F., Cathepsin B, UCSD Nature Molecule Pages, doi:10.1038/mp.a000508.01, http://www.signaling-gateway.org/molecule/query?afcsid=A000508, 2011, April, Invited, Online peer-reviewed publication.
Nouh MA, Mohamed MM, El-Shinawi M, Shaalan MA, Cavallo-Medved D, Khaled HM, Sloane BF, Cathepsin B: a
potential prognostic marker for inflammatory breast cancer, Journal of Translational Medicine, 9, 1-8, 2011, January.
Victor BC, Anbalagan A, Mostafa Mohamed M, Sloane BF, Cavallo-Medved D., Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion., Breast Cancer Research, 13,