Assistant Professor (Research)
540 E. Canfield, 6269 Scott Hall
B.S., Chemistry, Xavier University of Louisiana, New Orleans, LA, 2003
Ph.D., Physiology, Wayne State University, Detroit, MI, 2011
Areas of Research
Our lab studies the regulation of red cell-endothelial interactions using mass spectrometry and flow-based adhesion assays. We focus on very late antigen-4 (VLA-4), one of the most characterized adhesion receptors in SCD that supports avid interactions between blood cells and vascular cell adhesion molecule-1 (VCAM-1) expressed on the vascular endothelium. VLA-4 can assume multiple activation states that are functionally regulated by signaling pathways to activate adhesion. The overall goal of our work is to understand the regulation of VLA-4 in red cells. This regulation may reveal novel, therapeutic targets to aid in the development of alternative therapies to reduce red cell-interactions in SCD. Current research topics include 1) relationship between VLA-4 activity and adhesion; 2) cell signaling pathways that are altered in SCD and modulated by hydroxyurea; 3) kinases; 4) biomarkers; 5) microfluidics.
- Lancelot M, White J, Sarnaik S, Hines P. Low molecular weight heparin inhibits sickle erythrocyte adhesion to VCAM-1 through VLA-4 blockade in a standardized microfluidic flow adhesion assay. Br J Haematol 2017;178:479-81.
- White J, Krishnamoorthy S, Gupta D, et al. VLA-4 blockade by natalizumab inhibits sickle reticulocyte and leucocyte adhesion during simulated blood flow. Br J Haematol 2016;174:970-82.
- White J, Lancelot M, Sarnaik S, Hines P. Increased erythrocyte adhesion to VCAM-1 during pulsatile flow: Application of a microfluidic flow adhesion bioassay. Clin Hemorheol Microcirc 2015;60:201-13.
- White J, Lindgren M, Liu K, Gao X, Jendeberg L, Hines P. Sevuparin blocks sickle blood cell adhesion and sickle-leucocyte rolling on immobilized L-selectin in a dose dependent manner. Br J Haematol 2019;184:873-6.
- White JC, Pawar A, Fu G, et al. TR2/TR4 overexpression in a humanized sickle cell disease mouse model decreases RBC adhesion to VCAM-1. Blood Cells Mol Dis 2015;55:316-7.