Sokol  Todi

Sokol Todi

Associate Professor of Pharmacology and Neurology

stodi@med.wayne.edu

Sokol Todi

Office Address

3108 Scott Hall
540 E. Canfield, Detroit MI 48201

Office Phone

Office: 313-577-1173
Lab: 313-577-2522

Biography

Molecular pathways involved in neurodegeneration and neuroprotection.

Age-related neurodegeneration, including Alzheimer's Disease, Parkinson's Disease and Polyglutamine Diseases (e.g. Huntington's Disease), afflicts millions of people worldwide. Our understanding of molecular mechanisms involved in each of these diseases is incomplete, and no cures exist for them. By using a combination of in vitro biochemistry, mammalian cell biology and fruit fly (Drosophila melanogaster) genetics, our laboratory is working to identify and characterize genes important for neuronal homeostasis during normal function and in disease.

A major focus of our current work centers on the physiological functions of a large class of proteases known as deubiquitinating enzymes (DUBs). DUBs are critical regulators of numerous cellular pathways, and have recently emerged as potential therapeutic targets for various diseases, including neurodegenerative ones. Our work with DUBs, some of which themselves cause degeneration when mutated, is shedding new light into basic cell biology and identifying novel therapeutic targets and strategies.

Education

Baccalaureate:
University of Nebraska, Lincoln, NE, U.S.A.; 08/1995 – 05/1999
B.Sc. (Biological Sciences, Major; Psychology, Art History & Criticism, Minors), May, 1999

Graduate:
University of Iowa, Iowa City, IA, U.S.A.; 01/2000 – 05/2005
Laboratory of Dr. Daniel F. Eberl
Focus: Auditory mechanotransduction
Ph.D. in Neuroscience, May, 2005

Training

University of Iowa College of Medicine, Iowa City, IA, U.S.A.
Laboratory of Dr. Henry L. Paulson
Post-Doctoral training in neurodegeneration; 06/2005 – 06/2007

University of Michigan Medical School, Ann Arbor, MI, U.S.A.
Laboratory of Dr. Henry L. Paulson
Post-Doctoral training in neurodegeneration; 07/2007 – 08/2010

Awards and Honors

 While at the University of Nebraska – Lincoln
1999: Phi Beta Kappa National Honor Society.
1999: High Distinction Graduate.
1999: Superior Scholar.
1997: Scholastic Achievement & Excellence, Golden Key National Honor Society.
1995 – 1999: Dean’s List.
1995 – 1999: Distinguished Foreign Student Scholarship.
1995 – 1999: Certificate of High Scholarship.
1995 – 1997: Scholarship for Higher Education, Soros Foundation.

While at the University of Iowa
12/2006: Post-Doctoral Award, American Society for Cell Biology Annual Meeting.
01/2006: Research Fellowship, National Ataxia Foundation.
01/2004: Pre-Doctoral Fellowship, American Heart Association.
12/2003: Graduate Incentive Fellowship, University of Iowa.
11/2003: Graduate Student Travel Fellowship, Society for Neuroscience Meeting.


While at the University of Michigan
09/2009: K99/R00 Career Advancement Award, NINDS.
01/2008: Post-Doctoral Travel Award, American Society for Biochemistry and Molecular Biology Annual Meeting.

While at Wayne State University
10/2015: Award for Excellence in Research, WSU School of Medicine.
10/2014: Award for Excellence in Instruction and Teaching, WSU School of Medicine.
12/2012: Young Investigator in Spinocerebellar Ataxias, National Ataxia Foundation.
12/2011: Young Investigator in Spinocerebellar Ataxias, National Ataxia Foundation.

Publications

Faculty Status

Neuropharmacology
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Department of Pharmacology