Professor of Pharmacology and Neurology
540 E. Canfield, Detroit MI 48201
3108 Scott Hall
Age-related neurodegeneration, including Alzheimer's Disease, Parkinson's Disease and Polyglutamine Diseases (e.g. several Spinocerebellar Ataxias and Huntington's Disease), afflicts millions of people worldwide. Our understanding of molecular mechanisms involved in each of these diseases is incomplete and no cures exist for them. By using a combination of in vitro biochemistry, mammalian cell biology and fruit fly (Drosophila melanogaster) genetics, our laboratory is working to identify and characterize genes important for neuronal homeostasis during normal function and in disease. We have made great progress in recent years towards understanding mechanisms of disease as well as narrowing down on viable therapeutic approaches.
Another major focus of our work centers on the physiological functions of a large class of proteases known as deubiquitinating enzymes (DUBs). DUBs are critical regulators of numerous cellular pathways, and have recently emerged as potential therapeutic targets for various diseases, including neurodegenerative ones. Our work with DUBs, some of which themselves cause degeneration when mutated, is shedding new light into basic cell biology and identifying novel therapeutic targets and strategies.
Lastly, we recently expanded our work into novel processes important for protein quality control (proteostasis) during normal physiological activities as well as in diseases of the nervous system by centering on unconventional mechanisms involving the small protein modifier, ubiquitin.
Learn more about our work on: researchgate.net/profile/Sokol_Todi
University of Nebraska, Lincoln, NE, U.S.A.; 08/1995 – 05/1999
B.Sc. (Biological Sciences, Major; Psychology, Art History & Criticism, Minors), May, 1999
University of Iowa, Iowa City, IA, U.S.A.; 01/2000 – 05/2005
Laboratory of Dr. Daniel F. Eberl
Focus: Auditory mechanotransduction
Ph.D. in Neuroscience, May, 2005
University of Iowa College of Medicine, Iowa City, IA, U.S.A.
Laboratory of Dr. Henry L. Paulson
Post-Doctoral training in neurodegeneration; 06/2005 – 06/2007
University of Michigan Medical School, Ann Arbor, MI, U.S.A.
Laboratory of Dr. Henry L. Paulson
Post-Doctoral training in neurodegeneration; 07/2007 – 08/2010
Areas of Expertise
Polyglutamine diseases, age-related neurodegeneration, ubiquitin-dependent pathways, Drosophila genetics, biochemistry, mammalian cell biology
Areas of Interest
Diseases of the nervous system caused by misfolded proteins | Ubiquitin recycling | Neuronal and glial development
Awards and Honors
While at Wayne State University
12/2020: Award for Excellence in Research, WSU School of Medicine
02/2019: Pioneer Award in Spinocerebellar Ataxias, National Ataxia Foundation, USA
04/2017: Career Development Chair, WSU
10/2015: Award for Excellence in Research, WSU School of Medicine
10/2014: Award for Excellence in Instruction and Teaching, WSU School of Medicine
12/2012: Young Investigator in Spinocerebellar Ataxias, National Ataxia Foundation
12/2011: Young Investigator in Spinocerebellar Ataxias, National Ataxia Foundation
While at the University of Michigan
09/2009: K99/R00 Career Advancement Award, NINDS
01/2008: Post-Doctoral Travel Award, American Society for Biochemistry and Molecular Biology Annual Meeting
While at the University of Iowa
12/2006: Post-Doctoral Award, American Society for Cell Biology Annual Meeting
01/2006: Research Fellowship, National Ataxia Foundation
01/2004: Pre-Doctoral Fellowship, American Heart Association
12/2003: Graduate Incentive Fellowship, University of Iowa
11/2003: Graduate Student Travel Fellowship, Society for Neuroscience Meeting
While at the University of Nebraska – Lincoln
1999: Phi Beta Kappa National Honor Society
1999: High Distinction Graduate
1999: Superior Scholar
1997: Scholastic Achievement & Excellence, Golden Key National Honor Society
1995 – 1999: Dean’s List
1995 – 1999: Distinguished Foreign Student Scholarship
1995 – 1999: Certificate of High Scholarship
Continuously funded by the National Institutes of Health, non-governmental organizations (e.g. National Ataxia Foundation) and from internal WSU funds throughout tenure at Wayne State University.
My focus as a mentor is simple: my mentees and their long-term success and wellbeing. As a mentor to high school, undergraduate and graduate students, as well as postdocs and faculty, this focus has always remained sharp, although my approach to ensuring successful outcomes does vary with each mentee.
Each mentee is a different person with a different, fascinating and multi-faceted background; with different types of talent; with different and sometimes changing aspirations; and in need of different types of help. Thus, from the very inception of a mentoring relationship and plan, my mentee and I work together to understand each other’s goals and dreams, backgrounds, strengths and weaknesses. Often, I become a mentee myself and learn from those under my guidance and mentorship.
To ensure my mentees’ success and wellbeing, we work together to make sure that each of them has frequent and easy access to me in the laboratory and off campus. We interact often and informally. We ascertain that they are happy, safe, and secure — aspects that are necessary for unimpeded progress and success during their training and beyond. We work together to accomplish short- and long-term goals that we have devised collectively. We work together so that each mentee gradually reaches their full independence. We work together so that each mentee develops and follows ethical behavior and conduct at every level. We work together to ensure that each mentee knows that I will always be there for them, at any time of their lives.
Each mentee is a different person. Each deserves a different plan, approach, and timeline. Each should succeed in their own goals. And each must be treated with grace, respect and care.