Wei-Ling Tsou
Office Address
Department of Pharmacology
540 E. Canfield, 3108 Scott Hall
Detroit, Michigan 48201
Office Phone
313-577-2522
Training
Post-doctoral fellow
Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI, U.S.A.
Dr. Sokol Todi Labotory, 2011-2013
Research Associate
Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI, U.S.A.
Dr. Sokol Todi Labotory, 2013-2016
Education
Baccalaureate:
Taipei Medical University, Taipei, Taiwan.
B.Sc. in Nutrition and Health Sciences, June 1998.
Graduate:
Taipei Medical University, Taipei, Taiwan.
M.Sc. in Medical Sciences, June 2004.
National Yang Ming University, Taipei, Taiwan.
Exchange student in University of Michigan Medical School, Ann Arbor, MI, U.S.A.
Ph.D. in Neuroscience, June 2011.
Publications
Peer-Reviewed Publications:
- Sutton JR, Blount JR, Libohova K, Tsou W-L, Joshi GS, Paulson HL, do Carmo Costa M, Scaglione MK, Todi SV. Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3. Human Molecular Genetics, (2017) Feb 1. doi: 10.1093/hmg/ddx039. PMID: 28158474
- Tsou W-L, Qiblawi SH, Hosking RR, Gomez CM, Todi SV. Polyglutamine length-dependent toxicity from α1ACT in Drosophila models of spinocerebellar ataxia type 6. Biology Open. (2016) Dec 15;5(12):1770-1775. doi: 10.1242/bio.021667. PMID: 27979829
- Ristic G, Tsou W-L, Guzi E, Kanack A, Scaglione KM, Todi SV. USP5 is dispensable for mono-ubiquitin maintenance in Drosophila. Journal of Biological Chemistry, (2016) Apr 22;291(17):9161-72. doi: 10.1074/jbc.M115.703504. PMID: 26917723
- Tsou W-L, Ouyang M, Hosking RR, Sutton JR, Blount JR, Burr AA, Todi SV. The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila. Neurobiology of Disease. (2015) Oct; 82:12-21. doi: 10.1016/j.nbd.2015.05.010. PMID: 26007638
- Tsou W-L, Hosking RR, Burr AA, Sutton JR, Ouyang M, Du X, Gomez CM, Todi SV. DnaJ-1 and karyopherin α3 suppress degeneration in a new Drosophila model of Spinocerebellar Ataxia Type 6. Human Molecular Genetics, (2015) 24(15):4385-96. doi: 10.1093/hmg/ddv174. PMID: 25954029
- Blount JR*, Tsou W-L*, Ristic G, Burr AA, Ouyang M, Galante H, Scaglione KM, Todi SV. Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23. Nature Communications, (2014) 5:4638. doi: 10.1038/ncomms5638. PMID: 25144244 *Co-First Author
- Burr AA, Tsou W-L, Ristic G, Todi SV. Using membrane-targeted green fluorescent protein to monitor neurotoxic protein-dependent degeneration of Drosophila Eyes. Journal of Neuroscience Research, (2014) 92(9): 1100-09. PMID: 24798551
- Tsou W-L, Burr AA, Ouyang M, Blount JR, Scaglione KM, Todi SV. Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo. Journal of Biological Chemistry, (2013) 288(48): 34460-69. PMID: 24106274
- Tsou W-L, Sheedlo MJ, Morrow ME, Blount JR, McGregor KM, Das C, Todi SV. Systematic analysis of the physiological significance of Deubiquitinating Enzymes. PLoS ONE, (2012) 7(8): e43112. doi:10.1371/journal.pone.0043112. PMID: 22937016
- Tsou W-L, Soong BW, Paulson HL, Rodríguez-Lebrón E. Splice isoform-specific suppression of the Cav2.1 variant underlying spinocerebellar ataxia type 6. Neurobiology of Disease, (2011) Vol 43(3): 533-42. doi: 10.1016/j.nbd.2011.04.016. PMID: 21550405
Review Articles & Editorials:
- Ristic G, Tsou W-L, Todi SV. An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes. Front Mol Neurosci. (2014) Aug 19;7:72.
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