Michael Petriello

Michael Petriello

Assistant Professor

michael.petriello@wayne.edu

Michael Petriello

Office Address

6135 Woodward Avenue
IBio Room 2128
Detroit, MI 48202

Office Phone

313-577-1089

Biography

The goals of my research are directly relatable to understanding mechanisms that link nutrition and toxicology and may lead to translatable prevention strategies that may limit pollutant-induced metabolic disorders such as diabetes, obesity, and cardiovascular disease especially in at-risk populations. I also have strong experience and interest in using large data sets to uncover novel associations of environmental risk and cardiovascular disease as well as working with underserved communities that face multiple chemical and non-chemical stressors.

Overall, I aim to investigate biomarkers that link environmental exposures, diet, and metabolic diseases in human populations and to test mechanisms of toxicity using mouse models of cardiometabolic disease.

Education

Muhlenberg College, Allentown, PA, BS, Biology / Environmental Science, 05/2010
University of Kentucky, Lexington, KY, Ph.D., Toxicology, 05/2015

Training

Harvard Medical (Boston Children’s Hospital), Boston, MA,Visiting Scientist, Endocrinology, 2016

Fellowships

University of Kentucky, Lexington, KY, Postdoctoral Fellow, Cardiovascular Research Institute, 2016-2019

Areas of Expertise

  • Toxicology
  • Environmental Health
  • Cardiovascular Medicine
  • Metabolomics/Mass Spectrometry
  • Nutritional Sciences

Grants

 Current:

TMAO is a biomarker of dioxin-like pollutant exposure and cardiometabolic disease– K99R00ES028734

The goal of this career development grant is to increase knowledge in analytical chemistry, biostatistics and epidemiology with a focus on mechanisms linking diet and dioxin-like pollutant exposure to increased risk of atherosclerosis and cardiometabolic disease.

Past:

Transcriptional Effects of Per and Poly Fluorinated Alkyl Substances

The goal of this internal NIEHS Environmental Health Sciences Core Center grant is to provide funding to optimize high throughput screens to identify transcription factors relevant to PFAS toxicity.

NIH T32 Training Grant Recipient – 5T32HL091812-08

Post doctoral Fellowship in cardiovascular research. “Clinical Scholars in Cardiovascular Science”.

American Heart Association Great Rivers Affiliate Predoctoral Fellowship

Project title: Novel methodologies to study anti-inflammatory nitro-fatty acids.

Prior Appointments

Lexington, KY VA medical Center - WOC appointment

Publications

 Selected publications:

Petriello MC, Hoffman JB, Vsevolozhskaya O, Morris AJ, Hennig B: Dioxin-like PCB 126 increases intestinal inflammation and disrupts gut microbiota and metabolic homeostasis. Environmental Pollution. 2018 Nov;242(Part A):1022-1032. doi: 10.1016/j.envpol.2018.07.039. Epub 2018 Jul 17. PMID: 30373033

Petriello MC, Charnigo R, Sunkara M, Soman S, Pavuk M, Birnbaum L, Morris AJ, Hennig B.: Relationship between serum trimethylamine N-oxide and exposure to dioxin-like pollutants. Environmental Research. 2018 Apr;162:211-218. doi: 10.1016/j.envres.2018.01.007. Epub 2018 Jan 30. PMID: 29353125.

Petriello MC, Brandon JA, Hoffman J, Wang C, Tripathi H, Abdel-Latif A, Ye X, Li X, Yang L, Lee E, Soman S, Barney J, Wahlang B, Hennig B, Morris AJ,: Dioxin-like PCB 126 increases systemic inflammation and accelerates atherosclerosis in lean LDL receptor deficient mice. Toxicological Sciences. 2018 Apr 1;162(2):548-558. doi: 10.1093/toxsci/kfx275. PMID: 29216392.

Petriello MC, Hoffman J, Sunkara, Wahlang B, Perkins JT, Morris AJ, Hennig B: Dioxin-like pollutants increase hepatic flavin containing monooxygenase (FMO3) expression to promote synthesis of the pro-atherogenic nutrient biomarker Trimethylamine N-oxide from dietary precursors. Journal of Nutritional Biochemistry. 2016 Jul;33:145-53. doi: 10.1016/j.jnutbio.2016.03.016. Epub 2016 Apr 1. PMID: 27155921

AlSiraj Y, Chen X, Thatcher SE, Temel RE, Cai L, Blalock E, Katz W, Ali HM, Petriello M, Deng P, Morris AJ, Wang X, Lusis AJ, Arnold AP, Reue K, Thompson K, Tso P, Cassis LA. XX sex chromosome complement promotes atherosclerosis in mice. Nature Communications. 2019 June 14; 10(1):2631. doi: 10.1038/s41467-019-10462-z. PMID: 31201301

 

Faculty Status

Assistant Professor

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