Student and Postdoctoral Fellow Publications

Both Student and Postdoc Publications

LeFauve, Matthew K., Roxanne Bérubé, Samantha Heldman, Yu-Ting Tiffany Chiang, and Christopher D. Kassotis. 2023. "Cetyl Alcohol Polyethoxylates Disrupt Metabolic Health in Developmentally Exposed Zebrafish" Metabolites 13, no. 3: 359. https://doi.org/10.3390/metabo13030359

Roxanne Bérubé, Matthew K. LeFauve, Samantha Heldman, Yu-Ting Tiffany Chiang, Johnna Birbeck, Judy Westrick, Kate Hoffman, Christopher D. Kassotis. 2023. “Adipogenic and endocrine disrupting mixture effects of organic and inorganic pollutant mixtures” Science of The Total Environment, Volume 876. https://doi.org/10.1016/j.scitotenv.2023.162587

Student Publications

Bridget B. Baker, Alex S. Haimbaugh, F. Gianluca Sperone, Destiny M. Johnson, Tracie R. Baker, Persistent contaminants of emerging concern in a great lakes urban-dominant watershed, Journal of Great Lakes Research, Volume 48, Issue 1, 2022, Pages 171-182, ISSN 0380-1330, https://doi.org/10.1016/j.jglr.2021.12.001.

Phillips J, Haimbaugh AS, Akemann C, Shields JN, Wu CC, Meyer DN, Baker BB, Siddiqua Z, Pitts DK, Baker TR. Developmental Phenotypic and Transcriptomic Effects of Exposure to Nanomolar Levels of 4-Nonylphenol, Triclosan, and Triclocarban in Zebrafish (Danio rerio). Toxics. 2022 Jan 24;10(2):53. doi: 10.3390/toxics10020053. PMID: 35202241; PMCID: PMC8877790.

Postdoctoral Fellow Publications

Jessica R. Blount, Jeremiah N. Shields, Chia-Chen Wu, Camille Akemann, Bridget B. Baker, Zoha Siddiqua, Danielle N. Meyer, Nemer Hijazi, Zane Tolbert, David K. Pitts, Tracie R. Baker,
Phenotypic and transcriptomic effects of developmental exposure to nanomolar levels of pesticides in zebrafish,
Environmental Advances, Volume 7, 2022, 100151, ISSN 2666-7657, https://doi.org/10.1016/j.envadv.2021.100151.

Kassotis, C. D., LeFauve, M. K., Chiang, Y. T. T., Knuth, M. M., Schkoda, S., & Kullman, S. W. (2022). Nonylphenol Polyethoxylates Enhance Adipose Deposition in Developmentally Exposed Zebrafish. Toxics, 10(2), 99.

Sujkowski A, Richardson K, Prifti MV, Wessells RJ, Todi SV. Endurance exercise ameliorates phenotypes in Drosophila models of spinocerebellar ataxias. Elife. 2022 Feb 16;11:e75389. doi: 10.7554/eLife.75389. PMID: 35170431; PMCID: PMC8871352.

Yang, Z., Roth, K., Ding, J., Kassotis, C. D., Mor, G., & Petriello, M. C. (2022). Exposure to a mixture of per-and polyfluoroalkyl substances modulates pulmonary expression of ACE2 and circulating hormones and cytokines. Toxicology and Applied Pharmacology, 116284.

Kim, H., Fu, Z., Yang, Z., Song, Z., Shamsa, E. H., Yumnamcha, T., Sun, S., Liu, W., Ibrahim, A. S., Qi, N. R., Zhang, R., & Zhang, K. (2022). The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand. Molecular Metabolism, 101562. https://doi.org/10.1016/j.molmet.2022.101562

Roy, B., Yang, Z., Pan, G., Roth, K., Agarwal, M., Sharma, R., Petriello, M. C., & Palaniyandi, S. S. (2022). Exposure to the dioxin-like pollutant PCB 126 afflicts coronary endothelial cells via increasing 4-hydroxy-2 nonenal: A role for aldehyde dehydrogenase 2. Toxics, 10(6), 328. https://doi.org/10.3390/toxics10060328

Yang, Z., Stemmer, P. M., & Petriello, M. C. (2022). Proteomics-Based Identification of Interaction Partners of the Xenobiotic Detoxification Enzyme FMO3 Reveals Involvement in Urea Cycle. Toxics, 10(2), 60. https://doi.org/10.3390/toxics10020060

Student Publications

Herroon, M. K., Mecca, S., Haimbaugh, A., Garmo, L. C., Rajagurubandara, E., Todi, S. V., ... & Podgorski, I. (2021). Adipocyte-driven unfolded protein response is a shared transcriptomic signature of metastatic prostate carcinoma cells. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1868(11), 119101.

Johnson, S. L., Libohova, K., Blount, J. R., Sujkowski, A. L., Prifti, M. V., Tsou, W. L., & Todi, S. V. (2021). Targeting the VCP-binding motif of ataxin-3 improves phenotypes in Drosophila models of Spinocerebellar Ataxia Type 3. Neurobiology of disease, 160, 105516.

Rosati, R., Shahab, M., Ramkumar, V., & Jamesdaniel, S. (2021). Lmo4 deficiency enhances susceptibility to cisplatin-induced cochlear apoptosis and hearing loss. Molecular Neurobiology, 58(5), 2019-2029. https://pubmed.ncbi.nlm.nih.gov/33411315/

Roth, K., Yang, Z., Agarwal, M., Liu, W., Peng, Z., Long, Z., ... & Petriello, M. C. (2021). Exposure to a mixture of legacy, alternative, and replacement per-and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury. Environment International, 157, 106843.

Shahab M, Rosati R, Meyer DN, Shields JN, Crofts E, Baker TR, Jamesdaniel S. Cisplatin-induced hair cell loss in zebrafish neuromasts is accompanied by protein nitration and Lmo4 degradation. Toxicol Appl Pharmacol. 2021 Jan 1;410:115342. doi: 10.1016/j.taap.2020.115342. Epub 2020 Nov 25. PMID: 33245977; PMCID: PMC7775345.

Yang, Z., Roth, K., Agarwal, M., Liu, W., & Petriello, M. C. (2021). The transcription factors CREBH, PPARa, and FOXO1 as critical hepatic mediators of diet-induced metabolic dysregulation. The Journal of Nutritional Biochemistry, 95, 108633.

Postdoctoral Fellow Publications

Johnson SL, Libohova K, Blount JR, Sujkowski AL, Prifti MV, Tsou WL, Todi SV. Targeting the VCP-binding motif of ataxin-3 improves phenotypes in Drosophila models of Spinocerebellar Ataxia Type 3. Neurobiol Dis. 2021 Dec;160:105516. doi: 10.1016/j.nbd.2021.105516. Epub 2021 Sep 24. PMID: 34563642; PMCID: PMC8693084.

Sujkowski A, Hong L, Wessells RJ, Todi SV. The protective role of exercise against age-related neurodegeneration. Ageing Res Rev. 2022 Feb;74:101543. doi: 10.1016/j.arr.2021.101543. Epub 2021 Dec 17. PMID: 34923167; PMCID: PMC8761166.

Sujkowski A, Wessells R. Exercise and Sestrin Mediate Speed and Lysosomal Activity in Drosophila by Partially Overlapping Mechanisms. Cells. 2021 Sep 19;10(9):2479. doi: 10.3390/cells10092479. PMID: 34572128; PMCID: PMC8466685.

Student Publications

Blount, J. R., Meyer, D. N., Akemann, C., Johnson, S. L., Gurdziel, K., Baker, T. R., & Todi, S. V. (2019). Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster. Biology open, 8(5), bio043372.

Blount, J. R., Johnson, S. L., & Todi, S. V. (2020). Unanchored ubiquitin chains, revisited. Frontiers in Cell and Developmental Biology, 1081.

Johnson, S. L., Ranxhi, B., Libohova, K., Tsou, W. L., & Todi, S. V. (2020). Ubiquitin-interacting motifs of ataxin-3 regulate its polyglutamine toxicity through Hsc70-4-dependent aggregation. Elife, 9, e60742.

Miller CJ, Runge-Morris M, Cassidy-Bushrow AE, Straughen JK, Dittrich TM, Baker TR, Petriello MC, Mor G, Ruden DM, O’Leary BF, Teimoori S, Tummala CM, Heldman S, Agarwal M, Roth K, Yang Z, Baker BB. A Review of Volatile Organic Compound Contamination in Post-Industrial Urban Centers: Reproductive Health Implications Using a Detroit Lens. International Journal of Environmental Research and Public Health. 2020; 17(23):8755. https://doi.org/10.3390/ijerph17238755

Nuga, O., Meng, Y., Berezovsky, A., Nelson, K., & de Carvalho, A. (2020). EXTH-36. PHARMACEUTICAL INHIBITION OF CYCLIN DEPENDENT KINASE 4/6 (CDK4/6) IN GLIOBLASTOMA. Neuro-Oncology, 22(Suppl 2), ii94.

Sujkowski, A., Gretzinger, A., Soave, N., Todi, S. V., & Wessells, R. (2020). Alpha-and beta-adrenergic octopamine receptors in muscle and heart are required for Drosophila exercise adaptations. PLoS genetics, 16(6), e1008778.

Postdoctoral Fellow Publications

Blount, J. R., Johnson, S. L., & Todi, S. V. (2020). Unanchored ubiquitin chains, revisited. Frontiers in Cell and Developmental Biology, 1081.

Blount, JR, Johnson, SL, Libohova, K, Todi, SV, Tsou, W-L. Degron capability of the hydrophobic C-terminus of the polyglutamine disease protein, ataxin-3. J Neurosci Res. 2020; 98: 2096– 2108. https://doi.org/10.1002/jnr.24684

Blount JR, Libohova K, Silva GM, Todi SV. Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF-κB Signaling. Cells. 2020; 9(6):1519. https://doi.org/10.3390/cells9061519

Cobb T, Sujkowski A, Morton C, Ramesh D, Wessells R. Variation in mobility and exercise adaptations between Drosophila species. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2020 Jul;206(4):611-621. doi: 10.1007/s00359-020-01421-x. Epub 2020 Apr 25. PMID: 32335730; PMCID: PMC7314734.

Kim M, Sujkowski A, Namkoong S, Gu B, Cobb T, Kim B, Kowalsky AH, Cho CS, Semple I, Ro SH, Davis C, Brooks SV, Karin M, Wessells RJ, Lee JH. Sestrins are evolutionarily conserved mediators of exercise benefits. Nat Commun. 2020 Jan 13;11(1):190. doi: 10.1038/s41467-019-13442-5. PMID: 31929512; PMCID: PMC6955242.

Sujkowski A, Gretzinger A, Soave N, Todi SV, Wessells R. Alpha- and beta-adrenergic octopamine receptors in muscle and heart are required for Drosophila exercise adaptations. PLoS Genet. 2020 Jun 24;16(6):e1008778. doi: 10.1371/journal.pgen.1008778. PMID: 32579604; PMCID: PMC7351206.

Cao T, Sujkowski A, Cobb T, Wessells RJ, Jin JP. The glutamic acid-rich-long C-terminal extension of troponin T has a critical role in insect muscle functions. J Biol Chem. 2020 Mar 20;295(12):3794-3807. doi: 10.1074/jbc.RA119.012014. Epub 2020 Feb 5. PMID: 32024695; PMCID: PMC7086023.

The Glu-Rich C-Terminal Extension of Insect Troponin T is an Essential Structure Critical to Embryonic Development
A Sujkowski, T Cao, JP Jin, Biophysical Journal 118 (3), 258a-259a

Student Publications

Berezovsky, A., Nuga, O., Meng, Y., Poisson, L., Noushmehr, H., & deCarvalho, A. (2019). GENE-55. GENE EXPRESSION SIGNATURE ASSOCIATED WITH AGGRESSIVE GLIOBLASTOMA GROWTH IS ENRICHED IN CHROMATIN MODIFICATION AND STEMNESS TRANSCRIPTIONAL REGULATION PROGRAMS. Neuro-Oncology, 21(Suppl 6), vi109.

Blount, J. R., Meyer, D. N., Akemann, C., Johnson, S. L., Gurdziel, K., Baker, T. R., & Todi, S. V. (2019). Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster. Biology open, 8(5), bio043372.

Blount, J. R., Meyer, D. N., Akemann, C., Johnson, S. L., Gurdziel, K., Baker, T. R., & Todi, S. V. (2019). Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster. Biology open, 8(5), bio043372.

Johnson, S. L., Blount, J. R., Libohova, K., Ranxhi, B., Paulson, H. L., Tsou, W. L., & Todi, S. V. (2019). Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3. Neurobiology of disease, 132, 104535.

Nuga, O., deCarvalho, A., Ruden, D., Brown, S., Datta, I., & Malta, T. (2019). The influence of cellular developmental state on response to therapeutics in glioblastoma.

Rosati, R., Shahab, M., Neumann, W. L., & Jamesdaniel, S. (2019). Inhibition of protein nitration prevents cisplatin-induced inactivation of STAT3 and promotes anti-apoptotic signaling in organ of Corti cells. Experimental cell research, 381(1), 105-111. https://pubmed.ncbi.nlm.nih.gov/31078568/

Postdoctoral Fellow Publications

Blount, J. R., Meyer, D. N., Akemann, C., Johnson, S. L., Gurdziel, K., Baker, T. R., & Todi, S. V. (2019). Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster. Biology open, 8(5), bio043372.

Johnson, S. L., Blount, J. R., Libohova, K., Ranxhi, B., Paulson, H. L., Tsou, W. L., & Todi, S. V. (2019). Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3. Neurobiology of disease, 132, 104535.

Octopamine signaling through adrenergic receptors is necessary and sufficient for adaptations to chronic exercise training in Drosophila, R Wessells, A Sujkowski
Entomology 2019 (presentation)

Sujkowski A, Spierer AN, Rajagopalan T, Bazzell B, Safdar M, Imsirovic D, Arking R, Rand DM, Wessells R. Mito-nuclear interactions modify Drosophila exercise performance. Mitochondrion. 2019 Jul;47:188-205. doi: 10.1016/j.mito.2018.11.005. Epub 2018 Nov 6. PMID: 30408593; PMCID: PMC7035791.